Assay Development & optimization

Let us help you ensure accuracy and reliability so you can trust your data

assay development and optimization services

Mercodia is a company that has been developing and manufacturing ELISAs and ligand binding assays for commercial use for over 30 years. We have a deep understanding of product lifecycle management and employ product development procedures to ensure the reliability, accuracy, and precision of the assays we develop for bioanalysis in drug development. These procedures cover all phases of the lifecycle including design, development, validation, and routine use. Mercodia’s expertise in product development and manufacturing allows for smooth tech transfer of assays between laboratory facilities and from clinical studies to routine use. This makes our assays effective for long-term treatment monitoring or for use as companion diagnostics.

ligand binding assays

Ligand binding assays (LBAs) are widely used in drug development and key decisions are taken from the data. It is therefore important that the results are reliable. Our assay development services guarantee accurate and precise measurement of your biomarker of choice for the specific intended use, as well as for PK and PD studies. We deliver integrated bioanalytical solutions for your toughest assay needs.

Assay development

Design of antigen binders
Development of assays
Assay validation for the context of use
Assay manufacturing and supply (small and large scale)

Assay performance optimizations
- Reduction of interference
- Improvement of precision and reproducibility
- Lowering sample volume
- Shortening assay time

Sample matrix adaptations (adapting the assay for alternative matrix)
Ensure compliance with relevant guidelines

Immunocapture services

Immunocapture, or Hybrid LC-MS, is a widely used technique for sample preparation before measuring proteins and peptides in complex matrices. Using Mercodia’s extensive collection of antibodies or custom selected ones, we conjugate capture antibodies to magnetic beads for downstream analysis by LC-MS/MS, providing an additional level of separation. Thanks to our expertise in antibody characterization and binding interactions, we can also help you in design, mapping and characterization of antibodies or binding targets. This approach may improve quantification of clinically relevant complex molecules, such as proteins and hormones, with a sensitivity that meets clinical needs. Contact us for more information.

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