Liquid Chromatography Mass Spectrometry
LC-MS/MS is used in drug discovery by providing accurate and sensitive analysis of small molecules, quantifying drug concentrations, studying pharmacokinetics, identifying metabolites, screening compounds, and discovering biomarkers.
Liquid Chromatography Mass Spectrometry (LC-MS/MS)
Liquid Chromatography Mass Spectrometry (LC-MS/MS) is used in biomarker analysis to identify and quantify specific molecules or protein biomarkers associated with diseases or drug responses, guiding patient stratification, treatment selection, and personalized medicine approaches.
LC-MS/MS is also utilized for quantitative analysis of drugs and their metabolites in various biological samples, such as plasma, urine, or tissues. The technique offers high sensitivity, selectivity, and dynamic range, allowing for accurate and precise measurements of drug concentrations. This information is crucial for pharmacokinetic studies, assessing the absorption, distribution, metabolism, and excretion (ADME) of drugs, and determining the exposure and clearance of drug candidates.
When studying the pharmacokinetics of drug candidates, including ADME profiles, LC-MS/MS can also be used to optimize dosing regimens, evaluate bioavailability, assess drug-drug interactions, and guide formulation development.