HNL Homodimer ELISA – Advanced Biomarker for Sepsis Research
Mercodia’s HNL Homodimer ELISA provides precise, a cutting-edge immunoassay designed to measure the neutrophil-specific homodimeric form of Human Neutrophil Lipocalin (HNL), also known as NGAL. This unique biomarker offers exceptional value for research on bacterial infections and antibiotic response in sepsis.
Launch Offer
Get 25% off your first order with promo code TRYHNL25* when purchasing directly from Mercodia.
What makes HNL homodimer unique
The homodimeric form of HNL is released exclusively from activated neutrophils during bacterial infection. This makes it a highly specific and fast-responding biomarker, offering earlier and more accurate insight into infection dynamics and treatment efficacy.
✔ Neutrophil-specific biomarker
✔ Rapid response compared to CRP and PCT
✔ Reflects real-time infection dynamic
Why HNL Homodimer Matters in Sepsis Research
HNL is a glycoprotein stored in neutrophils and released upon activation. Its homodimeric form is uniquely neutrophil-specific, making it a precise indicator of infection-driven immune responses and antibiotic treatment success.
By binding bacterial siderophores and limiting iron availability, HNL supports innate immunity, positioning the homodimeric form as a valuable biomarker for bacterial sepsis research.
Common biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT) lack specificity for neutrophil activation. They often respond slowly, show limited ability to distinguish bacterial from viral infections, and do not reliably track early antibiotic treatment effects.
Key advantages with HNL Homodimer
✔ Highly specific, neutrophil-targeted biomarker
✔ Rapid and reliable detection of bacterial infection
✔ Superior to CRP and PCT for distinguishing bacterial vs viral infections
✔ Sensitive monitoring of antibiotic response and disease progression
✔ Supports early, evidence-based decision-making in sepsis research
Expert insights supporting HNL Homodimer
“The homodimeric form of HNL is a novel biomarker with great potential for studying antibiotic response in sepsis. We believe the HNL Homodimer ELISA is an excellent tool for bacterial sepsis research, offering superior and more dependable results compared with other typical biomarkers.”
— Gianni Garcia, Director R&D, Mercodia
“The HNL Homodimer is the superior biomarker to monitor the successful antibiotic treatment in patients with sepsis and other serious bacterial infections.”
— Per Venge, Professor, Uppsala University
technical specifications
- Monoclonal-based sequential sandwich ELISA
- 2 h 15 min incubation on 96-well plates
- Measures homodimeric HNL with colorimetric detection
- Sample volume: 5 µL (EDTA plasma)
- Measurement range: 0.039 – 5.0 µg/L
- <0.1% cross-reactivity with EPX/EDN, ECP, EPO, Lysozyme, MPO
Why Choose Mercodia Immunoassays?
✔ Easy-to-use
Ready-to-use calibrators, color-coded reagents, and simple protocols.
✔ Best-in-class technical support
Expert help within 24 hours, including direct access to assay developers.
✔ Long shelf life & stability
Kits last up to 3 years and tolerate up to 8 weeks at room temperature.
✔ High precision of delivery
Fast delivery within 1–2 days in EU/US from our global hubs.
Supporting Your Research from Start to Finish
Mercodia assays are engineered to deliver consistent performance in complex research environments. Whether you’re conducting basic science, investigating metabolic pathways or developing the next generation of therapeutics, our tools ensure the precision your work demands.
Support beyond the kit
Our scientific support team is here to help, from assay setup to troubleshooting and data interpretation. Whether you’re in early discovery or clinical development, we’re just a message away.
Ready to take your sepsis research further?
Questions? Contact us!
*The discount applies only to HNL kits at the current list price and is valid until March 31, 2026. To receive the discounted price, contact your local Mercodia sales representative or submit a quote request at www.mercodia.com/products.Orders must include the specified discount code: TRYHNL25. The discount can only be applied to customer purchases made directly through Mercodia. Other restrictions may apply.
