New Assay Launch: HNL Homodimer ELISA

Mercodia proudly introduces the HNL Homodimer ELISA (10-1380-01) – a cutting-edge immunoassay designed to measure the neutrophil-specific homodimeric form of Human Neutrophil Lipocalin (HNL), also known as NGAL. This unique biomarker offers exceptional value for research on bacterial infections and antibiotic response in sepsis.

A breakthrough biomarker for bacterial sepsis research

At Mercodia, we are committed to supporting researchers by providing accurate and precise tools for faster, more reliable results.

“The homodimeric form of HNL is a novel biomarker with great potential for studying antibiotic response in sepsis. We believe the new HNL Homodimer ELISA is an excellent tool for bacterial sepsis research, offering superior and more dependable results compared with other typical biomarkers,” says Gianni Garcia, Director of R&D, Mercodia.

What is HNL Homodimer?

Human Neutrophil Lipocalin (HNL) is a glycoprotein stored in neutrophils and released upon activation. Its homodimeric form is neutrophil-specific, making it highly relevant for infection-related processes. By binding bacterial siderophores and limiting iron availability, HNL plays a major role in innate immunity.

Why is it important?

Research by Venge et al. shows that homodimeric HNL offers a precise reflection of neutrophil activation in bacterial sepsis. Because its levels fall rapidly when treatment is effective, it enables sensitive monitoring of both disease progression and antibiotic response. This makes it a valuable complement to, and in many cases more informative than, traditional biomarkers such as C-reactive protein (CRP) and procalcitonin (PCT).

“The HNL Homodimer is the superior biomarker to monitor the successful antibiotic treatment in patients with sepsis and other serious bacterial infections” says Professor Per Venge, Uppsala University.

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Key advantages with HNL Homodimer 

✔ The HNL Homodimer is a novel biomarker with potential as research clinical tool for the study of antibiotic response in sepsis

✔ Elevated levels of HNL Homodimer have association with sepsis in critically ill patients

✔ HNL Homodimer has outperformed C-reactive protein (CRP) and procalcitonin (PCT) in the distinction between viral and bacterial infections

✔ HNL Homodimer has been shown superior to CRP and PCT for the detection of bacterial infection in sepsis patients

✔ HNL is a great tool for bacterial sepsis research and advancements

technical specifications

• <0.1% cross-reactivity with EPX/EDN, ECP, EPO, Lysozyme, MPO
• Monoclonal-based sequential sandwich ELISA
• Incubation time: 2 h 15 min 96-well plates
• Measures homodimeric HNL
• Colorimetric detection
• Sample volume: 5 µL (EDTA plasma)
• Measurement range: 0.039 – 5.0 µg/L

Ready to explore more?

Read more about HNL Homodimer ELISA and start advancing your sepsis research today.

*The discount applies only to HNL kits at the current list price and is valid until March 31, 2026. To receive the discounted price, contact your local Mercodia sales representative or submit a quote request at www.mercodia.com/products.Orders must include the specified discount code: TRYHNL25. The discount can only be applied to customer purchases made directly through Mercodia. Other restrictions may apply.